KSR modulates signal propagation within the MAPK cascade.
نویسندگان
چکیده
منابع مشابه
Signal propagation in the MAPK cascade: role of bistability and ultrasensitivity for a mixed problem
TheMAPK signaling cascade is nowadays understood as a networkmodule highly conserved across species. Its main function is to transfer a signal arriving at the plasma membrane to the cellular interior, the nucleus. Current understanding of ’how’ this is achieved involve the notions of ultrasensitivity and bistability which relate to the nonlinear dynamics of the biochemical network, ignoring spa...
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The MAPK signaling cascade is nowadays understood as a network module highly conserved across species. Its main function is to transfer a signal arriving at the plasma membrane to the cellular interior. Current understanding of 'how' this is achieved involves the notions of ultrasensitivity and bistability which relate to the nonlinear dynamics of the biochemical network, ignoring spatial aspec...
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The MAP kinase cascade is an important signal transduction system in molecular biology for which a lot of mathematical modelling has been done. This paper surveys what has been proved mathematically about the qualitative properties of solutions of the ordinary differential equations arising as models for this biological system. It focusses, in particular, on the issues of multistability and the...
متن کاملKSR, a novel protein kinase required for RAS signal transduction
We have identified and characterized two genes in Drosophila whose products are required for activated RAS to signal with normal efficiency, but do not appear to effect signaling by activated RAF. One encodes the beta subunit of type I geranylgeranyl transferase, a prenylation enzyme essential for targeting RAS to the plasma membrane. The other encodes a protein kinase that we have named kinase...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 1996
ISSN: 0890-9369
DOI: 10.1101/gad.10.21.2684